Scientists have known for decades that drastically restricting certain nutrients without causing malnutrition prolongs health and lifespan in a wide range of species, but the molecular mechanisms underlying this effect have remained a mystery. In a paper recently published in the journal Aging Cell , MDI Biological Laboratory scientist Aric Rogers , Ph.D., sheds light on an important genetic pathway underlying this process, raising the possibility that therapies can be developed that prolong the healthy years without having to suffering the consequences of a severely restricted diet.